Download PDF by Dr. Felix R. Althaus, Dr. Christoph Richter (auth.): ADP-Ribosylation of Proteins: Enzymology and Biological

By Dr. Felix R. Althaus, Dr. Christoph Richter (auth.)

ISBN-10: 3642830773

ISBN-13: 9783642830778

ISBN-10: 364283079X

ISBN-13: 9783642830792

In 1966, a paper entitled "On the formation of a unique adenylylic compound by means of enzymatic extracts of liver nuclei" from Paul Mandel's laboratory in Strasbourg, France, planted the seed for a swiftly growing to be new box of organic learn targeting ADP-ribosylation reactions. the improvement of this box over the last 2 a long time displays a great deal a latest development of organic study. As extra distinctive wisdom accumulates, enigmatic phenomena become innovations which create their very own enigmata. This approach has a tendency to desire the improvement of a number of, possible disconnected, learn traces till simplicity emerges from chaos and unifying recommendations alternative for controversy. it seems that the sphere of ADP-ribosylation reactions has now not but attained this latter level. for instance, with the identity of 2 diversified periods of ADP-ribosylation reactions, i.e., mono-ADP-ribosyla­ tion and poly-ADP-ribosylation reactions, the sphere cut up very early into separate branches of analysis. With the current quantity, we've got divided the duty of reviewing those sessions of ADP­ ribosylation therefore, even though their coexistence in eukaryotes may well contain a better practical linkage than hitherto recognized.

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Additional info for ADP-Ribosylation of Proteins: Enzymology and Biological Significance

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1983) et al. 5 Rat liver (Ueda et al. 1. 5 32 Enzyme B Rat testis (Burzio et al. 56 13 30 Physarum polycephalum (Tanaka et al. 3 16000 Cytosolic HeLa cells (Tanuma et al. 2 Human erythrocytes (Tanuma et al. <" ::l < 0 '"...... 8... 2. 8· 170, 1500·· f - 6 270-280 kD 75 kD subunits Exonucieolytic , Futai and Mizuno (1967). b Shinshi et al. (1976). c 1 unit liberates llLmol of paranitrophenol/min (cf. footnotes d and e). d With p-nitrophenyl uridine 5' -phosphate as substrate . • With p-nitrophenyl thymidine 5' -phosphate as substrate.

1982) performed a systematic analysis of the structural requirements of a chemical for inhibition of poly(ADP-ribose) synthesis in nucleotidepermeable cells. They examined analogs of various parts of the NAD molecule and correlated their inhibitory potential with the presence or absence of specific substitutions. 9. 7. -1M) Bromodeoxyuridine (2 mM) Bromouracil (5 mM) Bromouridine (2mM) Caffeine (2 mM) Cyclic AMP (5 mM) Cyclic dTMP Deamino-NAD (5 mM) Deoxyguanosine Deoxythymidine 5' -diphosphate Deoxythymidine 5' -mono phosphate Deoxythymidine 5' -triphosphate 98 14 27 14 90 21 45 10 46 25 36 41 45 16 21 30 75 90 96 71 Purnell and Wish (1980a) Preiss et al.

In: Hayaishi 0, Ueda K (eds) ADP-ribosylation reactions. Academic Press, London New York, pp 139-141 Ueda K, Zhang J, Hayaishi 0 (1985) Immobilized poly(ADP-ribose) synthetase: preparation and properties. In: Althaus FR, Hilz H, Shall S (eds) ADP-ribosylation of proteins. Springer, Berlin Heidelberg New York Tokyo, pp 47-51 Werner E, Sohst S, Gropp F, Simon D, Wagner H, Kroger H (1984) Presence ofpoly(ADP-ribose) polymerase and poly(ADP-ribose) glycohydrolase in the dinoflagellate crypthecodinium cohnii.

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ADP-Ribosylation of Proteins: Enzymology and Biological Significance by Dr. Felix R. Althaus, Dr. Christoph Richter (auth.)

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