By Charles F. Streckfus
This publication experiences the development made in salivary diagnostics in the past 20 years and identifies the most probably path of destiny endeavors. After an introductory part describing the histological and anatomical good points of the salivary glands and salivary functionality, salivary assortment units and diagnostic structures are reviewed. the sector of “salivaomics” is then thought of intimately, masking, for instance, proteomics, the peptidome, DNA and RNA research, biomarkers, and strategies for biomarker discovery. Salivary diagnostics for oral and systemic ailments are completely mentioned, and the function of salivary gland tissue engineering for destiny diagnostics is explored. The ebook closes by means of contemplating felony matters and obstacles to salivary diagnostic improvement. Advances in Salivary Diagnostics may be an informative and stimulating reference for either practitioners and students.
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Additional info for Advances in Salivary Diagnostics
2008;139(2): 25S–34. 21. Fine DH, Furgang D, Beydouin F. Lactoferrin iron levels are reduced in saliva of patients with localized aggressive periodontitis. J Periodontol. 2002;73(6): 624–30. 22. Valenti P, Berlutti F, Conte MP, Longhi C, Seganti L. Lactoferrin functions: current status and perspectives. J Clin Gastroenterol. 2004;38(6):S127–9. 23. Walz A, Stühler K, Wattenberg A, Hawranke E, Meyer HE, Schmalz G, et al. Proteome analysis of glandular parotid and submandibular-sublingual saliva in comparison to whole human saliva by twodimensional gel electrophoresis.
In litigation, questions also may arise regarding specific methods of collection. A method of collection must be consistent with preservation of the integrity of the specimen before tests. As an illustration, if the use of citrate to stimulate saliva flow could be proven to, even remotely, interfere with assayed substances, results of such tests may prove unreliable [4, 99]. The FDA approval/validation of both methods of saliva collection and laboratory procedures for assays is likely to be a requirement for insurance reimbursement.
P53, cathepsin D, cyclin E, and kallikrein 14 have now been added to the list as protein-based potential biomarkers of breast cancer [36, 64, 65]. Messenger RNA (mRNA) expression-based platforms such as MapQuant Dx™ Genomic Grade (based on the expression of about 100 genes for breast cancer detection) and the RT-PCR-based assay system, BCtect™ with several genes for early detection, are now available . There are also reports suggesting that a number of microRNAs (miRNA), including mir-125b, mir-145, mir-21, and mir-155, known to be dysregulated in breast cancers be considered among the list of candidate biomarkers for 23 breast cancers [66, 67].
Advances in Salivary Diagnostics by Charles F. Streckfus