Read e-book online Alzheimer’s Disease Pathogenesis-Core Concepts, Shifting PDF

By Suzanne De La Monte

ISBN-10: 9533076909

ISBN-13: 9789533076904

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Extra resources for Alzheimer’s Disease Pathogenesis-Core Concepts, Shifting Paradigms and Therapeutic Targets

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The merged image (C) of panels (A) and (B) reveals colocalization of these proteins (yellow).

Data were analyzed using ANOVA and Fisher’s PLSD-test (Stat View®; SAS Institute Inc, Cary, NC. USA). Other data were expressed as mean±SD and analyzed using ANOVA. 05 was considered statistically significant. 3. 1-3). Neurons, astroglia or microglia were identified by immunohistochemical staining using anti-NF, anti-MAP-2, and anti-GFAP or anti-CD11b, respectively. Double labeling immunohistochemistry with anti- 36 Alzheimer’s Disease Pathogenesis-Core Concepts, Shifting Paradigms and Therapeutic Targets NF (Fig.

In a recent study, Zhao and Townsend are demonstrated that insulin resistance and Aβ disrupt common signal transduction cascades including the insulin receptor family/Phosphoinositide 3-kinase/Akt/Glycogen synthase kinase3(GSK3) pathway. They reported that both disease processes contribute to overlapping pathology, thereby compounding disease symptoms and progression (Zhao & Townsend, 2009). The age-associated decline in the metabolic rate and utilization of glucose by the frontal cortex imply that insulin resistance can cause executive dysfunctions in older people, not only global cognitive impairment.

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Alzheimer’s Disease Pathogenesis-Core Concepts, Shifting Paradigms and Therapeutic Targets by Suzanne De La Monte


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