New PDF release: Anatomy of a Scientific Discovery: The Race to Find the

By Jeff Goldberg

ISBN-10: 1626361932

ISBN-13: 9781626361935

In past due 1973, scientists John Hughes and Hans Kosterlitz spent the vast majority of their time in an underfunded, vague, and cramped laboratory in Aberdeen, Sweden. whereas engaged on the brains of pigs, the duo stumbled on a nonaddictive narcotic chemical that they was hoping to later locate in human brains. in the event that they may isolate this chemical in people, might be they can have the option to assist the area start to heal itself. Hughes and Kosterlitz’s examine could unavoidably cause them to observe endorphins, the body’s personal ordinary morphine and the chemical that makes it attainable to consider either discomfort and pleasure.

Announcing their findings to the clinical global thrust Hughes and Kosterlitz within the highlight and made them celebrities. quickly, scientists around the globe have been rapidly interpreting the human mind and its endorphins. In many years’ time, they'd use the team’s preliminary learn to hyperlink endorphins to drug dependancy, runner’s excessive, urge for food keep watch over, sexual reaction, and psychological health problems akin to melancholy and schizophrenia.

In Anatomy of a systematic Discovery, Jeff Goldberg describes Hughes and Kosterlitz’s lives earlier than, in the course of, and after their ancient and clinical step forward. He additionally takes a glance on the higher photo, revealing the brutal festival among drug businesses to discover how to profit from this enormous discovery.

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Extra resources for Anatomy of a Scientific Discovery: The Race to Find the Body's Own Morphine

Sample text

During the fall of 1971, Akil decided to investigate the narcotizing action of brain stimulation as if it were a narcotic, seeing if she could reverse the SPA effect with nalorphine, an “antagonist” drug known to effectively block the effects of opiates. Akil chose the tail-flick test, using five rats freshly implanted with electrodes in their PAG, to study the problem. Each rat’s tail was placed over a small light bulb, and usually it took about three seconds for the animal, feeling the heat, to flick its tail away.

It would be almost impossible for the small, slow, and steady to win any scientific race in 2013. 7 in the mid-1990s by a small group of researchers at Stony Brook University. 7 appeared to be a crucial gateway for pain signals. It was an intriguing finding, but it took a massive collaboration between nineteen scientists in five countries, funded by the drug giant Pfizer Pharmaceuticals, to reveal the molecular gate’s true potential. The multinational research team analyzed the DNA of children born with a congenital insensitivity to pain.

Aberdeen University was by no means a place renowned for successful scientists. The faculty members were solid and respectable, but—to Hughes’s way of thinking—they did not work very hard; in many cases, they did no original research at all and were in some ways as archaic as the academic gowns many still wore to their lectures. More than once—and in no uncertain terms—he had told some distinguished senior faculty member simply to “stuff it,” and Kosterlitz, although he could be almost as temperamental in the privacy of the lab, often found himself publicly in the long-suffering father role, making excuses for his younger colleague.

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Anatomy of a Scientific Discovery: The Race to Find the Body's Own Morphine by Jeff Goldberg


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